Gamma-Hydroxybutyric acid (GHB) is another name for
the generic drug sodium oxybate. Xyrem (which is sodium
oxybate) is the trade name of the Food and Drug Administration
(FDA)-approved prescription medication.

Analogues that are often substituted for GHB include
GBL (gamma butyrolactone) and 1,4 BD (also called
just “BD”), which is 1,4-butanediol. These analogues are
available legally as industrial solvents used to produce
polyurethane, pesticides, elastic fibers, pharmaceuticals,
coatings on metal or plastic, and other products.

They are also sold illicitly as supplements for bodybuilding, fat
loss, reversal of baldness, improved eyesight, and to combat aging, depression, drug addiction, and insomnia. GBL and BD are sold as “fish tank cleaner,” “ink stain remover,” “ink cartridge cleaner,” and “nail enamel remover” for approximately $100 per bottle — much more expensive than comparable products. Attempts to identify the abuse of GHB analogues are hampered by the fact that routine toxicological screens do not detect the presence of
these analogues.

GHB is produced illegally in both domestic and foreign
clandestine laboratories. The major source of GHB on the
street is through clandestine synthesis by local operators.
At bars or “rave” parties, GHB is typically sold in liquid
form by the capful or “swig” for $5 to $25 per cap. Xyrem
has the potential for diversion and abuse like any other
pharmaceutical containing a controlled substance.

GHB has been encountered in nearly every region of
the country.

What are common street names?
Common street names include:
Easy Lay, G, Georgia Home Boy, GHB, Goop, Grievous
Bodily Harm, Liquid Ecstasy, Liquid X, and Scoop

What does it look like?
GHB is usually sold as a liquid or as a white powder that is
dissolved in a liquid, such as water, juice, or alcohol. GHB
dissolved in liquid has been packaged in small vials or small
water bottles. In liquid form, GHB is clear and colorless and
slightly salty in taste.

How is it abused?
GHB and its analogues are abused for their euphoric and
calming effects and because some people believe they build
muscles and cause weight loss.

GHB and its analogues are also misused for their ability to
increase libido, suggestibility, passivity, and to cause amnesia
(no memory of events while under the influence of the
substance) — traits that make users vulnerable to sexual
assault and other criminal acts.

GHB abuse became popular among teens and young adults at
dance clubs and “raves” in the 1990s and gained notoriety as
a date rape drug. GHB is taken alone or in combination with
other drugs, such as alcohol (primarily), other depressants,
stimulants, hallucinogens, and marijuana.

The average dose ranges from 1 to 5 grams (depending on the
purity of the compound, this can be 1-2 teaspoons mixed in a
beverage). However, the concentrations of these “home-brews”
have varied so much that users are usually unaware of the actual
dose they are drinking.

What is its effect on the mind?
GHB occurs naturally in the central nervous system in very small
amounts. Use of GHB produces Central Nervous System (CNS)
depressant effects including:
Euphoria, drowsiness, decreased anxiety, confusion, and
memory impairment

GHB can also produce both visual hallucinations and —
paradoxically — excited and aggressive behavior. GHB
greatly increases the CNS depressant effects of alcohol and
other depressants.

What is its effect on the body?
GHB takes effect in 15 to 30 minutes, and the effects last 3 to 6
hours. Low doses of GHB produce nausea.
At high doses, GHB overdose can result in:
Unconsciousness, seizures, slowed heart rate, greatly slowed
breathing, lower body temperature, vomiting, nausea, coma, and death

Regular use of GHB can lead to addiction and withdrawal
that includes:
Insomnia, anxiety, tremors, increased heart rate and blood
pressure, and occasional psychotic thoughts

Currently, there is no antidote available for GHB intoxication.

GHB analogues are known to produce side effects such as:
Topical irritation to the skin and eyes, nausea, vomiting,
incontinence, loss of consciousness, seizures, liver damage, kidney failure, respiratory depression, and death

What are its overdose effects?
GHB overdose can cause death.

Which drugs cause similar effects?
GHB analogues are often abused in place of GHB. Both GBL
and BD metabolize to GHB when taken and produce effects
similar to GHB. CNS depressants such as barbiturates and methaqualone also
produce effects similar to GHB.

What is its legal status in the United States?
GHB is a Schedule I controlled substance, meaning that it has
a high potential for abuse, no currently accepted medical use in
treatment in the United States, and a lack of accepted safety for
use under medical supervision. FDA-approved GHB products are
Schedule III substances under the Controlled Substances Act. In
addition, GBL is a List I chemical. It was placed on Schedule I of the Controlled Substances Act in March 2000. However, when sold as FDA-approved GHB
products (such as Xyrem), it is considered Schedule III, one of
several drugs that are listed in multiple schedules.

SOURCE: A DEA Resource Guide 2017 Edition